HKBU and CUHK launch Spermine Risk Score for prostate cancer diagnosis
08 Feb 2021
Professor Gary Wong Ka-leung, Professor and Head of the Department of Chemistry at HKBU, and Professor Ng Chi-fai and Dr Peter Chiu Ka-fung, Professor and Associate Professor respectively of the Division of Urology in the Department of Surgery at CU Medicine, have jointly developed the Spermine Risk Score which, coupled with the use of a urine test, provides a non-invasive and more reliable method for the diagnosis of prostate cancer. In a study conducted by the researchers, about 37% of the patients, who were ultimately found to have no prostate cancer, can avoid undergoing a prostate biopsy procedure. The findings have just been published in the scientific journal Prostate Cancer and Prostatic Diseases.
Dr Chiu said that, “This study confirms that urine spermine and the Spermine Risk Score are effective at identifying men at higher risk of prostate cancer and the test could help reduce the number of unnecessary biopsies.”
“It is the ﬁrst prospective study to investigate the efficacy of urine spermine in prostate cancer detection. It successfully demonstrated that the Spermine Risk Score, developed based on patients’ urine spermine levels and other clinical parameters, can serve as a novel and promising approach to address the limitations of the diagnostic methods currently in use,” said Professor Wong.
“Although there are a number of blood and urine adjuncts to guide prostate biopsy decisions in patients with elevated PSA levels, urine spermine is a convenient non-invasive test that doesn’t require another blood test or attentive DRE before specimen collection. Thus it minimises any potential complications associated with the procedures,” said Professor Ng.
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