Chinese medicine PhD student wins first prize in “Challenge Cup” National College student contest
01 Dec 2017
Lu Jun, a PhD student of the School of Chinese Medicine (SCM), recently won the First Prize for his research thesis in the Fifteenth “Challenge Cup” National College Students’ Extracurricular Academic Science and Technology Works Contest held in Shanghai University. He is the first SCM student to receive this prize. His award-winning project is entitled “Develop a Highly Water Soluble Nucleolin Aptamer Paclitaxel Conjugate with a Cathepsin Labile Linker for Tumour Specific Targeting in Breast Cancer”.
The project mainly studied the preparation of a conjugate containing a cathepsin labile linker that linked up paclitaxel (PTX) with nucleolin aptamer (NucA). This conjugate exhibited great water solubility, homogeneity and storage stability. The NucA modification facilitated the selective accumulation of the conjugated PTX in tumour tissues, resulting in notably improved antitumour activity and reduced toxicity. This work laid the foundation for the development of a new generation of aptamer-drug conjugate.
Dubbed the Olympic for college students’ science and technology innovations, the “Challenge Cup” National College Students’ Extracurricular Academic Science and Technology Works Contest is organised biennially by the China Association for Science and Technology, the Ministry of Education and other organisations that aims at fostering the development of young innovative talents.
This year, the competition attracted contestants from more than 2,000 higher education institutions to submit over 600,000 science and technology innovation projects. After the preliminary rounds of the Contest, a total of 1,230 projects were shortlisted for the final round, among which 102 projects were awarded the First Prize.